BERTIS


Panomics Analysis Service & Solution

PASS

PASS is an analysis solution optimized for academia and pharma research.
The proprietary solution was derived from proven technology and innovation
embedded in Mastocheck, a proteomics-based early cancer diagnostics approved
by Ministry of Food and Drug Safety (MFDS).

PASS is a platform for integrative analysis of pan-omics data, based on our proven and reliable bioinformatics analysis capabilities. Our team consists of experienced scientists with an extensive track record of research achievements spanning more than 15 years in mass spectrometry and integrated data interpretation.

Bertis possesses the core expertise and proprietary technology for pan-omics (multi-omics) analysis to provide customized solutions in all fields where omics data analysis is applicable.
PASS not only provides frontier biological systems research based on top-tier expertise and leading edge infrastructure and equipment, allows you to reduce resources and increase success rate associated with clinical trials.

With PASS, you can leverage Bertis’ scientific resources and cutting-edge tools to advance your research projects and goals, from the design stage to the interpretation and visualization of bioinformatics analysis results.

Service Brochure
  • Integrated Proteomics
  • Targeted Proteomics
  • Single Cell Proteomics
  • Lipidomics

Integrated Proteomics

We identify various proteins within different samples using mass spectrometry-based methods and analyze quantitative changes to provide protein information associated with specific diseases or conditions.
PASS offers optimized services tailored to the needs of our customers using the ProteoID platform, including COFFER, BTS MS, BTS Reads, and BTS Systems.

Application

biomarker discovery, drug target discovery, PTM analysis, pharmaceutical CMC quality control
(exosome, PROTAC), characterization and process analysis of protein therapeutics (ADC, HCP)

Post-Translational Modification (PTM) Analysis

Provide analysis of PTMs (Post-Translational Modifications) in proteins that are difficult to interpretaste through RNA information.
Quantitative analysis of modified proteins and amino acids for the major in vivo PTMs (Phosphorylation, Acetylation, Methylation, Ubiquitination, Glycosylation).

Pharmaceutical CMC Quality Control

Quality control (QC) of novel drug modality such as exosomes and TPD (Targeted Protein Degradation; PROTAC)

Analysis of extracellular vesicle (exosome) therapeutics

Provide information for quality management to ensure equivalence and compliance to the ‘Development of Production Process and Quality Control Guidelines for Exosome-Based Therapeutics’ provided by the Ministry of Food and Drug Safety.

Analysis package: Comparative profiling of proteins, lipids, and RNA

TPD (Targeted Protein Degradation) Analysis

Provide the quantitative results of target protein degradation and regulation of downstream pathway proteins in response to drug treatment.
Bioinformatics analysis to elucidate the impact of off-target proteins. This approach allows us to under stand the effects exerted on off-target proteins in a comprehensive manner.

Analysis package: Proteomics and bioinformatics analysis

Targeted Proteomics

PASS provides accurate quantitative results based on targeted mass spectrometry approach such as MRM (Multiple Reaction Monitoring) and PRM (Product Reaction Monitoring) analysis.
This method utilizes internal standards (IS) in the form of isotopically labeled surrogate peptides for each target.
We have developed and provide a reproducible results that meets the validation guidelines outlined by the Ministry of Food and Drug Safety. This method ensures high reproducibility with a coefficient of variation (CV) of less than 15%.

Application

quality control of protein therapeutics (HCP), absolute quantification of proteins within samples, biomarker validation

Biopharmaceutical Quality Control (HCP)

We are capable of verifying the purity during the separation and purification of monoclonal antibody drugs and cell-based therapeutics.

Analysis package: Mass spectrometry-based analysis method
(Semi, Absolute quantification) as an alternative to ELISA analysis

Single Cell Proteomics

Single-cell technologies can serve as a starting point for the development of
effective personalized therapies and cures for diseases. In particular,
mass spectrometry-based single-cell proteomics provides unbiased results.
Bertis has introduced Bruker’s timsTOF SCP system, which provides meaningful
results even in true single-cell level.

Application

drug target discovery, spatial biology

Lipidomics

Lipids, consisting of over 4,000 diverse compounds, are present in various tissues and cellular compartments of the human body. They are being applied not only in cancer research but also in metabolic disease studies. The PASS service provides identification and quantification of lipids in samples using representative standard substances. Additionally, we provide profiling results of exosomal lipid composition according to the guidelines of the Ministry of Food and Drug Safety.

Application

quality analysis of new drugs (exosomes), Biomarker discovery

  • What is the process for PASS service?

  • What mass spectrometry instrument is utilized for PASS service?

  • What is the minimum sample requirement for sample preparation?

  • How should the sample be delivered?

  • How is QC conducted for the amount of protein?

  • Is sample preparation performed by the client?

  • How is LC-MS/MS analysis performed?

  • What kind of results are provided?

  • How long will it take?

Please use this form to submit your inquiry for Bertis PASS. We will be happy to review your request and respond in a timely manner.
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  • Personal information collected: Your Name, Email, Contact, Company Name, Occupation
  • Purpose of data collection and use: Confirm the delivery of customer inquiries, contact the inquirer for fact checking, provide answers, notify inquiry results
  • Period of retention and use of personal information: To be retained for one year after the purpose of collection and use of personal information is met

* You have the right to refuse to consent to the collection and use of your personal information, and if you do not agree to these terms, your access to the service may be restricted.
* Your personal information will be destroyed without delay one year after the purpose of collecting and using personal information is met. However, if there is a duty to preserve personal information in accordance with Korean law or ordinance, it will be preserved for a certain period specified by the law.
  • Basis for data retention: Records on contract or subscription withdrawal, etc.
  • Retention period: 5 years

** Records of contracts, withdrawal of subscription, etc.: 5 years (Act on the Consumer Protection in Electronic Commerce, etc.)
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** Records of handling customers’ complaints or disputes: 3 years (Act on the Consumer Protection in Electronic Commerce, etc.)


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